The focus of Dr. Misra’s research has been on obesity, metabolic syndrome (syndrome X), diabetes mellitus, hyperlipidemia and other cardiovascular risk factors in Asian Indians and rare disorders of adipose tissue.
For the first time, Dr. Misra’s team showed a high prevalence of Type 2 Diabetes Mellitus, abdominal obesity, dyslipidemia and metabolic syndrome in the underprivileged population living in urban resettlement colonies of New Delhi. Other previously unreported observations on the same population included a high prevalence of hyperhomocysteinemia, endothelial dysfunction and subclinical inflammation. His team also carried out epidemiological study of metabolic syndrome and cardiovascular risk factors of post-menopausal women belonging to low socio-economic stratum, and reported a marked clustering of cardiovascular risk factors.
Current Research Projects:
1. To evaluate the impact of consumption of a bioactive compound extracted from fermented yeast on fasting blood glucose levels in Asian Indians with pre-diabetes: A randomized placebo-controlled double-blind parallel arm trial. 2024-25.
2. Effect of low-calorie diet and lifestyle intervention on reversal of type 2 diabetes mellitus, hepatic and pancreatic fat: A two-year randomized control trial in New Delhi, India. (CURE-DM). 2023-26.
3. Randomized controlled trial of almond supplementation vs. isocaloric diet on cognitive functions in middle-aged (40-60 years) Asian Indians with prediabetes. 2022-25.
4. The effect of metformin treatment on surrogate markers of ageing (leukocyte telomere length and telomerase activity), longevity gene expression (sirtuin 1, p66Shc, p53, and mammalian target of rapamycin), in north Indian Individuals with the prediabetes: A randomized control trial. 2022-2024.
5. To see the presence of complication including hepatic fibrosis in newly diagnosed diabetes (Fortis CDOC project supported by DFI) 2023.
6. Use of Artificial Intelligence and Machine Learning in Cardiovascular Risk prediction in Urbanised South Asians 2023.
7. The effect of metformin treatment on surrogate markers of ageing (leukocyte telomere length and telomerase activity), longevity gene expression (sirtuin 1, p66Shc, p53, and mammalian target of rapamycin), in north Indian Individuals with the prediabetes: A randomized control trial 2022-24.
8. To see the presence of complication including hepatic fibrosis in newly diagnosed diabetes (Fortis C-DOC project supported by DFI 2022-2023.
9. To assess prevalence of Sarcopenia using Hand grip strength (HGS) as a marker in patients with T2DM (Fortis C-DOC project supported by DFI 2022-2023.
10. A Case control study to compare prevalence of liver fibrosis in patients with acanthosis and non- A acanthosis 2023.
11. A randomized controlled study to compare effects of mango ingestion on glycemia (as per glycemic response, continuous glucose monitoring and fructosamine), insulin resistance and body composition in patients with type 2 diabetes mellitus (T2DM) and non-diabetic subjects Randomized control trial of vitamin D supplementation on surrogate markers of aging, glycemic and metabolic markers in north Indian with the prediabetes 2021-23.
12. Effects of metformin therapy on pancreatic and hepatic fat content using 3.0 Tesla Magnetic Resonance Imaging Proton Density Fat Fraction Software in patients of Type 2Diabetes Mellitus when treated according to current guidelines Protocol: Prospective Open Labe Case Control 16 weeks Proof of Concept Study 2020-21.
13. To identify anytime hyperglycaemia in subjects with normoglycemia and prediabetes. (Fortis C-DOC project supported by DFI2020 Self-funded.
14. Randomized control trial of vitamin D supplementation on surrogate markers of aging, glycemic and metabolic markers in north Indian with the prediabetes Indian Council of Medical Research (ICMR) 019-22.
15. Effects of Sodium Glucose Co-Transporter 2 Inhibitor Therapy on Pancreatic and hepatic fat content using 3.0 Tesla Magnetic Resonance Imaging Proton Density Fat Fraction Software in patients of Type 2 Diabetes Mellitus when treated according to current guidelines Protocol: Prospective Open Label Case Control 16 weeks Proof of Concept Study. Fortis C-DOC project supported by DFI) AstraZeneca, 2019-21.
16. Women initiative on prevention of diabetes (GDM/T2DM) and its risks (e.g., overweight or obesity) (NDOC project supported by DFI) World Diabetes Foundation (WDF) 2018-22.
17. Evaluation of pre-meal load of raw almonds on postprandial hyperglycemia and other metabolic responses in Asian Indians with prediabetes Almond Board of California2017-22.
18. The influence of Vitamin D Receptor (VDR) gene polymorphisms (BsmI, TaqI, ApaI, FokI) on weight loss by diet and exercise interventions in non-diabetic overweight and obese subjects Indian Council of Medical Research (ICMR) 2015-18.
19. Diabetes care on Wheels- Diabetes Rath World Diabetes Federation2015-18.
20. Prevention of type 2 diabetes in women with pre-diabetes using vitamin D supplementation and lifestyle intervention in North India DST, New Delhi, India 2013-17.
21. A randomized controlled trial to evaluate the effects of high Protein Complete (l A cto) VE geta R ian (PACER) diet in non-diabetic obese Asian Indians in North India Indian Council of Medical Research (ICMR) 2011-14.
22. Effect of high-protein meal replacement on weight and cardiometabolic profile in overweight/obese Asian Indians in North India Herbalife International India Pvt. Ltd. 2011-14.
23. Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome: a randomized double-blind control trial Self-funded2011-14.
24. Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians- a randomized controlled, parallel arm study PepsiCo India2010-12.
- Effect of vitamin D supplementation on surrogate markers of atherosclerosis in north Indian Individuals with pre-diabetes and low vitamin D levels: a 24-week randomised controlled trial: Indian Council of Medical Research (ICMR) 2022-2024, Grant amount: 1,00,32,200- Year 2022-2024
- Randomized Controlled Trial of Almond Supplementation vs. Isocaloric Diet on Cognitive Functions in Middle-aged (40-60 years) Asian Indians with Prediabetes, Sponsor: Almond Board of California, Grant amount: 2,24,40,000- Year 2022-2024
- A randomized controlled study to compare effects of mango ingestion on glycemia (as per glycemic response, continuous glucose monitoring and fructosamine), insulin resistance and body composition in patients with type 2 diabetes mellitus (T2DM) and non-diabetic subjects, Sponsor: Indian Council of Medical Research, Grant amount: 57,00,000, Year 2020-2022
- Evaluation of pre-meal load of raw almonds on postprandial hyperglycemia and other metabolic responses in Asian Indians with prediabetes, Sponsor: Almond Board of California , Grant amount: 1,80,00,000: Year 2019-2022
1. The influence of polymorphisms of fat mass and obesity (FTO, rs9939609) and vitamin D receptor (VDR, Bsml, Taql, Apal, Fokl) genes on weight
loss by diet and exercise interventions in non-diabetic overweight/obese Asian Indians in North India, Sponsor: Indian Council of Medical
Research, Grant amount: 61 Year: 2015-18
2. Effect of Almond Supplementation on Glycemia and Cardiovascular Risk Factors in Asian Indians in North India with Type 2 Diabetes Mellitus: A 24-
Week Study, Sponsor: Almond Board of California, Grant amount: Year: 2010-2012
3. Vitamin D Supplementation in Overweight/obese Asian Indian Women with Prediabetes Reduces Glycemic Measures and Truncal Subcutaneous
Fat: A 78 Weeks Randomized Placebo-Controlled Trial (PREVENT-WIN Trial), Sponsor: Department of Science and Technology, Grant amount:
Year: 2013-18
4. Randomized Control Trial for Reduction of Body Weight, Body Fat Patterning, and Cardiometabolic Risk Factors in Overweight Worksite Employees
in Delhi, India. Sponsor: Abbott India Ltd, Grant amount: Year: 2014-17
5. Body Fat Patterning, Hepatic Fat, and Pancreatic Volume of Non-Obese Asian Indians with Type 2 Diabetes in North India: A Case-Control Study,
Sponsor: Merck, Grant amount: Year: 2011-2014
6. Effect of a high-protein meal replacement on weight and cardiometabolic profile in overweight/obese Asian Indians in North India, Sponsor:
Herbalife International India Pvt Ltd, Grant amount: Year: 2012-15
7. Effects of 3 g of soluble fiber from oats on lipid levels of Asian Indians – a randomized controlled, parallel arm study, Sponsor: PepsiCo India, Grant
amount: ,Year: 2012-14
8. Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome: a randomized double-
blind control trial. Sponsor: Diabetes Foundation (India), Grant amount: Year: 2014-16
9. Diabetes care on Wheels- Diabetes Rath, Sponsor: World Diabetes Federation. Grant amount: 1 Year: 2015-18
10. To determine the effect of PACER diet (High Protein Atkin’s Complete Vegetarian Diet) in obese subjects. Sponsor: Indian Council of Medical
Research, Grant amount: Year: 2011-14
11. Effects of pistachio nuts on body composition, metabolic, inflammatory, and oxidative stress parameters in Asian Indians with metabolic
syndrome: a 24-week, randomized control trial. Sponsor: Paramount Farms Inc. Grant amount: Year: 2010-12
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